In the 5 years of utilizing CBD Cannabidiol, a clear treatment path and added arsenal for inflammation reduction, sleep quality improvement and calming of the racing and stressed mind has never been more applicable than now. Treating and recovering from Bursitis, Tendonitis, Inflammation from over use of wrists, joints in the fingers from massage therapy and inflammation and pain from sports and exercise are problems that have personally plagued me for years. CBD and Turmeric are two items along with consciously seeking low inflammation foods, such as raw sashimi (fish), shell fish, crustacean foods, managing high acidity foods such as taking in simple sugars from fruits rather than complex sugar foods from deserts, soft drinks and sugary beverages etc., have helped to alleviate and recover from these persistent recurring problems.
The question now was whether the other 96 or 119+ cannabinoids could either enhance the effects of CBD or have other therapeutic effects individually or utilized together.
With high quality and potency Cannibigerol CBG widely available now, the chance to incorporate CBG into our lives was seized.
In the available test tube, animal and human studies for CBG and CBD;
MDPI and ACS Style
Mammana, S.; Cavalli, E.; Gugliandolo, A.; Silvestro, S.; Pollastro, F.; Bramanti, P.; Mazzon, E. Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol. Medicina 2019, 55, 747.
In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid
by Agnese Gugliandolo 1,Federica Pollastro 2OrcID,Gianpaolo Grassi 3,Placido Bramanti 1 andEmanuela Mazzon 1,*OrcID
1. IRCCS Centro Neurolesi “Bonino Pulejo”, 98124 Messina, Italy
2. Department of Pharmaceutical Sciences, University of Eastern Piedmont “Amedeo Avogadro”, 28100 Novara, Italy
3. Research Centre for Industrial Crops, Council for Agricultural Research and Economics (CREA-CIN), 45100 Rovigo, Italy
Brierley, D.I., Samuels, J., Duncan, M. et al. Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology 233, 3603–3613 (2016). https://doi.org/10.1007/s00213-016-4397-4
Chapter 72 – The Role of 5-HT1A Receptor, and Nausea and Vomiting Relief by Cannabidiol (CBD), Cannabidiolic Acid (CBDA), and Cannabigerol (CBG)
Author links open overlay panel E.M.Rock, L.A.Parker
Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada
there were a few common themes referencing potential therapeutic effects of combining the use of Cannabigerol and Cannabidiol together to encourage the entourage effect (how phyto-cannabinoids interact and enhance and/or negate their isolated effects), to reduce neuro inflammation, oxidative stress and assisting in increasing appetite. However the same question is proposed of dosing, ratio of CBG and CBD, timing of dosing are areas required for further study.
For this instance, White CBG from Game Up Nutrition was utilized stand alone through out various parts of the day, evening and night times for 7 consecutive days. The White CBG was similar to a muscle and mood relaxant. After the 7 day consecutive regiment, the regiment was modified utilizing CBG only once per day in combination with 30mg dose of Game Up Nutrition CBD tincture taken 30min. before bed time daily. So far after consistent use for 2 weeks further regiments of CBG and CBD entourage effects to improve restful sleep, pain reduction and inflammation response after delayed onset muscle soreness from exercise is warranted. In Chapter 72 of the cited item above, it indicated CBD and CBG compete and bind to the same 5HT14 receptor. Furthermore Higher doses of CBG may block or interfere with CBD uptake when both are present. At lower doses the interference of CBD uptake are marginal. The specific dose and ratios are not provided. Additional research and continuous sustained combined, separated use will be necessary over the long term to gauge their combined effects.
Although the reporting is only anecdotal testimony, updates of progress will be noted here. In the mean time we would love to learn of your first hand experiences with combined regiments of CBG and CBD with a comment below.
Mahalo for your support.