Zelenko Pre Exposure Prophylaxis Protocol (PrEP) Complete

Updated September 14, 2020

Zelenko-PReP-Quercetin-Zinc-VitaminC-EGCG
Quercetin, Zinc, Green Tea EGCG, Vitamin C
Effective August 16, 2020 based on Dr. Vladimir Zelenko’s recommendations for (PrEP), a Pre Exposure Prophylaxis Protocol was implemented and completed to enhance Safety Measures effective April 2020 for Covid19.
(PrEP) daily dose regimen;
  1. 500mg of Quercetin (Substitute for HCQ, Ivermectin for use as Zinc Ionophore)
  2. 400mg of EGCG Green Tea extract or Green Tea (Substitute for HCQ, Ivermectin for use as Zinc Ionophore)
  3. 25mg of Elemental Zinc
  4. 1gram of Vitamin C
  5. 62.5mcg or 2500IU of Vitamin D per recommendation from Dr. Roger Seheult of Medcram . Fortifying additional Vitamin D with daily sun light minimum 10 – 15min. and supplement Vitamin D fortified foods
  6. Melatonin under review per Dr. Paul Marik MATH+ Protocol
  7. Famotidine (Pepcid) under review per Dr. Paul Marik MATH+ Protocol
  8. Budesonide (Rhinocort) under review per Dr. Richard P. Bartlett, MD, Alexandria Watkins, DNP
There was compiled research and people speaking of Quercetin and EGCG being zinc ionophores. Doing more research into zinc and zinc ionophores. Dr. Zelenko and Dr. Seheult compiled very useful updated data including initial In Vitro test tube and cell culture studies. These studies show zinc ionophores facilitate the transport of zinc through the cell membrane, increasing intra-cellular concentration of zinc inside of the cell or cell cytosol / cytoplasm inhibiting viral replication of various RNA viruses which include corona viruses. When the reasons Dr. Zelenko was recommending this regimen and clarified further by Dr. Seheult, the decision was made to implement this prophylaxis protocol.

This protocol was implemented as a Plan B regiment as the items above are inexpensive, highly accessible without a prescription, available at virtually any health food store and able to be fortified with foods such as onion, berries, green tea, meats, oysters etc.

Calculation for elemental zinc was based on the National Institutes of Health indicating 23% of Zinc Sulfate or 50mg of Elemental Zinc is contained in every 220mg of Zinc Sulfate.

https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

(25mg / 0.23) = daily dose of 109mg of Zinc Sulfate daily intake will equal 25mg of Elemental Zinc. Currently increasing Elemental Zinc dosage 7mg a week to see how if any adverse effects are observed and supplement any remaining deficiency in daily Zinc intake with Foods High in Zinc to achieve 25mg of Elemental Zinc intake per day.

List of Quercetin and Zinc High Foods

According to Healthline Article, 1 cup of green tea provides 50mg – 100mg of EGCG

Safety Measures effective April 1, 2020

*Guest intake and servicing continues with updated intake protocols. Reception and Massage Therapists / Estheticians will assist to facilitate updated procedures in consideration for maximum safety of guests and therapists possible at this time. Reception will assist in providing a brief Health Questionnaire during the booking and confirmation process.

*For the Current Duration couples and 2 people appointments at the same time are suspended to reduce the number of people in the treatment room and shop premises to reduce the risk of viral particulate concentration build up in enclosed spaces from breathing.

*For couples and groups of two people and greater, servicing one guest at a time in sequence with a 15 minute cleaning, disinfecting and set up time in between each appointment will be performed. For guests awaiting treatment, please make use of our waiting room to relax and unwind. We appreciate your understanding with reducing crowding.

*For each guest appointment, the entire shop is dedicated to each and every single guest which eliminates crowding in enclosed spaces.

*Currently using in personal and professional settings, mix of Hand woven masks, Surgical Masks, 3M N95 Respirator masks during guest appointments, with particular emphasis on proper fitting, wash or removal and disposal procedures after use.

*Currently using in personal and professional settings, 91% Isopropyl Alcohol to disinfect surfaces, hands, body extremities. The ramp up in use of Alcohol has been one of the most utilized and most valuable items to stock for personal and professional use.

*Thorough disinfection of surfaces are performed after each guest appointment utilizing 70% to 91% Isopropyl Alcohol.

*Currently using in personal and professional settings when necessaryindustrial goggles not completely air tight but sufficient to encapsulate eyes from direct and diagonal droplets projectiles.

*All Sheets, Towels, Head covers are bleached with washing after each use.

*For Guests Please bring a comfortable mask with you and wear your mask during the duration of the appointment and treatment. Mahalo

Zelenko Protocol Updates

September 10, 2020 Tuvia Doron posts Dr. Zelenko interview reiterates HCQ is not dangerous and clarifies the side effect profile.

September 3, 2020 Dr. Been Medical Lectures interviews Dr. Zelenko and reviews the history of how the Zelenko Protocol came into fruition and provides updates to the protocol discussing the role of Quercetin and Ivermectin.

Hydroxychloroquine Studies Compiled at;

https://www.palmerfoundation.com.au/articles/research-studies-and-clinical-trials/

August 28, 2020 Steamboat Institute speaks with Stanford University Hoover Institute’s Dr. Scott Atlas clarifying the mechanism of action for Hydroxychloroquine (HCQ).

https://www.palmerfoundation.com.au/hydroxychloroquine-very-safe-says-dr-scott-atlas-blasts-garbage-medical-studies/

August 24, 2020 Dr. Zelenko’s solution to end the Pandemic

Dr. Vladimir Zev Zelenko author of Metamorphisis is a family primary care outpatient doctor and clinician from New York. In April 2020 his New York Times piece sparked a great deal of interest in his early intervention outpatient care of high risk patients over the age of 60 and / or patients with comorbidities, utilizing his Zelenko Protocol to treat Covid19 experiencing an 84% reduction in hospitalizations and a reduction of mortality from 5% to 0.71%.

Zelenko Covid-19 Prophylaxis Protocol

Zelenko Covid-19 Treatment Low and High Risk Group Protocol

Zelenko Protocol PrePrint

Dr. Zelenko Published Results of Zelenko Protocol

FDA Emergency Use Authorization Overhaul Act of 2020

Dr. Zelenko Twitter

Sanctity of Patient Doctor Relationship in Honolulu Tarnished

As a brick and mortar business servicing guests in close contact for prolonged periods of time in enclosed spaces, there is an urgent need for pre exposure prophylaxis protocol (PrEP) to increase the confidence of safety, comfort and protection for our guests, therapists and everyone here at Honua Therapy. Refining and evolving existing safety measures as more evidence and data comes in is an imperative. The search for tools to help solve this problem started at the end of March 2020. Dr. Zelenko’s work was discovered through this effort. Outside of America, much to our delight and dismay, treatments that may work or have been working to defend against this disease do exist.

Zelenko Protocol Plan A regimen was preferred as more evidence and research exists. Plan A prophylaxis path was to utilize a more potent zinc ionophore, immunological and anti viral proposed mechanisms of action of Hydroxychloroquine or Ivermectin off label with elemental Zinc and elements of MATH+ protocol including Vitamin D and C.

Reviewing all body of literature available including proposed regimens and doses used in prophylaxis and early out patient treatment protocols from case, retrospective, observational, meta, prospective randomized clinical trials domestically and internationally, we have become aware of the overwhelming empirical evidence of clinical successes, biological plausibility, proposed mechanisms of actions, their safety and side effect profiles. With the information reviewed, 100% consent to the use of Ivermectin and HCQ Off Label with elemental Zinc and elements of MATH+ protocol including Vitamin D and C to utilize as prophylaxis, maybe the missing variable in solidifying effective safety measure protocols.

We have been requesting for care locally through our PCP, hospitals, clinics here in Honolulu, Hawaii for the last 5 months and every doctor, clinician and nurse practitioner we sought for care refuse to help or even see us to confer (PrEP) Pre Exposure Prophylaxis Protocols for Covid 19 specifically an off label non indicated conditions prescription assistance for Ivermectin and HCQ.

The last resort was our primary care provider at Makahiki clinic. She could not help us indicating that their policy does not allow for off label prescription of Hydroxychloroquine for prophylaxis purposes and referred us to another doctor who maybe able to help. Currently in the process of seeking out this doctor and scheduling an appointment. In parallel the search for other outpatient doctors out of state continues with a pivot towards off label prescription of Ivermectin for prophylaxis in parallel with HCQ.

Great Harm has been caused to us and our community as our first hand experiences with the private and public healthcare system doctors here in Honolulu over the prior months have violated the sanctity of the doctor patient relationship according to the Geneva Declaration of 1948, as factors other than evidence based medicine have tarnished this sacred relationship. For this reason seeking urgent care out of state from clinicians who will help us to prevent spread of this disease surging in our county now became the course of action.

What has come to our attention is that there are doctors and nurses self administering Hydroxychloroquine (HCQ) as prophylaxis and prescribing to their patients off label specifically clinicians that are self employed operating their own practice or in secret under fear of termination from their tenure or job, retaliation from their medical or pharmacology boards.

What has also come to our attention is that doctors and clinicians at least in Hawaii are well within their legal authority to prescribe medications such as Hydroxychloroquine and Ivermectin for use in off label non indicated conditions with the patients informed consent. In these cases it appears the doctor having knowledge of the treatment paths available and perhaps the patient having done their due diligence will weigh the safety, side effect profiles, drug interactions, any current health conditions against the benefits of the medication. The doctor and patient will decide together within the confines and privacy of the doctor patient relationship.

August 29, 2020 Sky News Australia speaks with Dr. Kulvinder Kaur Gill reminds us of the Geneva Declaration of 1948 forming the International Code of Medical Ethics and mitigating doctor’s acts of crimes against humanity. The critical importance of the doctor’s conscience in the practice of medicine and how the sanctity of the patient doctor relationship has been violated, when factors other than evidence based medicine and science interfere in the doctor patient relationship which is what we witness with HCQ restrictions. Doctor’s have the ability to prescribe existing approved medications for non indicated conditions called Off Label Use. People must understand that there are two distinct stages to this disease. First stage is the viral replication stage where you experience flu like symptoms. Second stage is severe pneumonia, hyper immune response attacking the heart, lungs and vital organs.

In search for answers to this urgent problem Dr. Gill describes, several questions about the American Clinical practice of medicine came to mind.

  1. In a time of emergency, why are these mature inexpensive and affordable medications and treatments prescribed and administered abroad being withheld from us and the public in America?
  2. Why will no doctors, clinicians and nurses help us prevent spread?
  3. Why was Dr. Zelenko’s miraculous care of his patients unreported on local media here in Hawaii?
  4. Is doing nothing actually doing no harm?
  5. Are doctors thinking about their own interests over their patients and community in this emergency situation?
  6. Why are we not doing research in parallel with actual administration of repurposed therapeutics using the best data, knowledge and tools we have available at present and start saving lives, reduce needless suffering and reduce the spread of this disease as India, South Korea, Peru and other countries are doing?
  7. Why is all the overwhelming scientific evidence for these treatment paths, safety profiles and side effect profiles being ideologically subverted and ignored?
  8. How are the economically disadvantaged, unemployed, out of business and uninsured going to afford to pay out of pocket for inpatient hospital care, and expensive inpatient treatments?
  9. Why 6 months into the pandemic are there still no early out patient treatments and prophylaxis protocols widely available and accessible?

At the start of answering these grave concerns, Former CDC Director Dr. Thomas R Frieden’s paper Evidence for Health Decision Making – Beyond Randomized, Controlled Trials from the New England Journal of Medicine

https://www.nejm.org/doi/10.1056/NEJMra1614394

and Psychiatrist, Psycho Analyst Norman Doidge, author of The Brain that Changes Itself and The Brain’s Way of Healing Piece from Tablet Magazine titled Medicine’s Fundamentalists

https://www.tabletmag.com/sections/science/articles/randomized-control-tests-doidge

provided a criteria for evaluating all data not just randomized controlled clinical data.

In addition the two key points used to form a framework for this measure were the FDA guidelines for Emergency Use Authorization of medications which are;
  1. There must be no other therapeutics available
  2. That the medication maybe effective.

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/emergency-use-authorization-medical-products-and-related-authorities

Meta, Safety, Retrospective, Observational, Prospective Randomized Control Clinical Trials compiled and updated for Hydroxychloroquine available at;

https://www.palmerfoundation.com.au/articles/research-studies-and-clinical-trials/

https://www.c19study.com

We had to pivot to how other doctors, clinicians were fighting this disease out of state along with other health systems and practices of medicine abroad to see how Zelenko’s Protocol and treatment paths for similar patient groups were being cared for presently. Drawing from the experience of many experts including Director General of India Council for Medical Research (ICMR) Balram Bhargava, Dr. Thomas Borody, Former CDC Director Dr. Thomas Freiden, Norman Doidge, Dr. Kulvinder Kaur Gill, Dr. Jean Jacques Rajter, Dr. Juliana Cepelowicz Rajter, Dr. Trevor Marshall, Dr. Harvey Risch, Dr. Raphael Stricker, MedCram and WhiteBoard Doctors expertise were received for consideration. This post is a compilation of data that allowed the reasoning to try Pre Exposure Prophylaxis protocols utilizing the available data.

Dr. Vladimir Zelenko Protocol

August 31, 2020 Original video was removed by Youtube, Kevin Boyle reposts a segment of this interview with Dr. Zelenko. 

August 26, 2020 Dr. Zelenko and Rabbi Katzin discuss the new retrospective inpatient Hydroxychloroquine study from Italy. Out of 70 Hydroxychloroquine studies, there is overwhelming evidence. 58 out of the 70 having positive effect, 12 studies negative and the Lancet study being retracted.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31324-6/fulltext

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext

Lancet HCQ Study Retraction Details

Medcram analysis of the Retracted Lancet Study reiterates further the supplier of the data for the study Surgisphere failed to provide to the Lancet, the requested data and methods of how they aggregated and networked the various hospital data used in the study for independent verification causing the retraction. On page 11 of the memorandum from the FDA regarding the revocation of the EUA for hydroxychloroquine on June 15, 2020, the memorandum cites the retracted study as part of the basis for the revocation of the EUA for HCQ 10 days after the Lancet study was retracted on June 5, 2020.

https://www.fda.gov/media/138945/download

On August 31, 2020 Dr. Vladimir Zelenko provides updates to the Zelenko Protocol. Emphasizes that picking out and risk stratifying which patients must be treated is the most important part of the protocol. Dr. Zelenko speaks briefly that his practice of medicine is also an art and must be tailored for each patient and their specific situation, emphasizing Zinc is the most important component. Dr. Zelenko speaks of the therapeutics Quercetin if Hydroxychloroquine is unavailable, Ivermectin an anti-parasitic medication, Doxycycline, Azythromycin antibiotics, Dexamethasone steroid and Budesonide regimen prescribed as an early high risk outpatient treatment program and prophylaxis. 

Dr. Zelenko also provides a Plan B Protocol for patients and people unable to access Hydroxychloroquine stratified into Low Risk Patient Regiment and High Risk patient regiment for Clinicians in the document below. 

https://faculty.utrgv.edu/eleftherios.gkioulekas/zelenko/Zelenko-memo-August-protocol.pdf

Zelenko Protocol PrePrint

Dr. Zelenko Published Results of Zelenko Protocol

July 14, 2020 Dr. Yogendra from Dr. Yo confers with Dr. Zelenko reviewing the details of the Zelenko Protocol and his perspective on the practice of medicine to save lives and keep his patients out of hospitals during this emergency situation. Dr. Zelenko refers to his practice of medicine, battlefield medicine.

WhiteBoard Doctor Analysis of Dr. Zelenko’s Protocol

Quality of Evidence and P Values

WhiteBoard Doctor clarifies the quality of evidence for consideration while undertaking research ranked from highest quality to lowest quality below;

  1. Meta Analysis and Systematic Reviews
  2. Critically Appraised Topics and Articles
  3. Randomized Controlled Trials (RCT)
  4. Cohort Studies
  5. Case Controlled Studies, Case Series and Reports
  6. Background Information and Expert Opinions

WhiteBoard Doctor clarifies the significance of P values in studies. For samples and groups a P value of greater than 0.05 is desired which indicates a well matched and balanced samples.

For results and outcomes a P value of less than 0.05 means there is statistical significance. The difference in Statistical significance and Clinical significance is when the statistically significant indication can be verified in clinical settings and corroborated by clinicians and doctors.

Crash Course in Zinc and Zinc Ionophores

Dr. Seheult of Medcram provides a beautiful illustration of how Zinc works to inhibit viral replication and Zinc Ionphore significance in assisting Zinc ions to transport through the cell wall to increase intra-cellular concentrations of Zinc.

Significance of Vitamin D, C, Zinc, Quercetin, NAC against Viral Infections and Covid-19

Dr. Seheult of Medcram provides updates going over new studies including randomized controlled studies and a ten year long retrospective study of the role of Vitamin D’s effect on cancers and viral infections including Covid-19.

Vitamin D Analog Calcefidiol May Reduce Bradykinin Storm

Dr. Seheult of Medcram provides updates going over Bradykinin hypothesis and how a new randomized controlled double blind study looks at of the role of dosing Calcefidiol 532mcg on day 1 and 266mcg on days 3 and 7, an analog of Vitamin D in alleviating the adverse effects inflammation, fluid build up, heart, lung, kidney complications from the Bradykinin storm in Covid-19 patients.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/pdf/main.pdf

https://elifesciences.org/articles/59177/figures

High Fructose Corn Syrup Adverse Effects on Vitamin D Assimilation

Dr. Seheult of Medcram provides useful data on the adverse effects of High Fructose Corn Syrup and the mechanisms of how High Fructose causes oxidative stress affecting the angio tenson II to angio tenson 17 conversion. Angio tenson 17 is the inhibitor of superoxide which induces an environment conducive for the formation of superoxides. According to studies highlighted, high fructose may interfere with the metabolizing of the active form of Vitamin D.

HCQ and Ivermectin Pre Exposure Prophylaxis and Treatment Studies

September 13, 2020 WhiteBoard Doctor provides an in depth analysis of a Belgian Retrospective Observational Cohort study of 8075 Covid-19 patients treated with low dose HCQ treatment of 2400mg of HCQ over a five day duration. Patients were sick inpatients. Study reveals the patient group treated with low dose HCQ resulted in a mortality rate was 17% whereas the non treatment group mortality rate was 27% showing statistical significance. Caveat for this study was that the treatment group and non treatment group were not well matched and balanced.

https://www.sciencedirect.com/science/article/pii/S0924857920303423

September 6, 2020 WhiteBoard Doctor provides an in depth analysis of a Observational Case series of 100 patients treated with Ivermectin and Doxycycline. Study reveals patients achieved viral and symptom clearance by 72 hours. Caveat for this study is that there was no control group that did not receive treatment to compare the 100 patient treatment group.

http://www.bcpsjournal.org/mhcms-admin/media/pdf/article762.pdf

September 3, 2020 WhiteBoard Doctor provides an in depth analysis of a Randomized Control Trial conducted at Zagazig University in Sharkia Egypt to observe Ivermectin’s efficacy as Prophylaxis for asymptomatic family members with close contact to PCR positive Covid-19 family members. The study measures any symptoms and positive PCR during a 14 day duration of the close contacts. Results show statistical significance for the group administered Ivermectin vs. the non administered group indicating Ivermectin’s prophylactic effects against Sars-Cov-2 infection. However the preprint below is not the complete study. Further details of the published study should provide additional insight into Ivermectin’s effectiveness as prophylaxis.

https://clinicaltrials.gov/ct2/show/study/NCT04422561

WhiteBoard Doctor provides an in depth analysis of a Cohort Trial for HCQ For Pre-Exposure Prophylaxis Against COVID-19:

https://www.medrxiv.org/content/10.1101/2020.06.09.20116806v2

Dr. Raphael Stricker specialist in the areas of Hematology, Immunology for Infectious Diseases provides a unique insight for the use of HCQ as a pre exposure prophylaxis based on the safety profile, 40 day half life duration of HCQ. His insight draws from his unique experience treating and researching tick born illnesses such as Babesia and mosquito born diseases such as Malaria for clues on preventatives for Covid-19.

https://www.trialsitenews.com/pre-exposure-prophylaxis-for-covid-19-lessons-from-the-past-and-the-search-for-new-options/

Pre Exposure Prophylaxis for Covid-19 Disease

https://osf.io/tm9r4/

MATH+ Protocol Dr. Paul Marik Eastern Virginia Medical School

July 18, 2020 Dr. Paul Marik, author of the MATH+ Protocol and Chief of Pulmonary and Critical Care at the Eastern Virginia Medical School at Norfolk Virginia speaks on the coalition of doctors providing care utilizing MATH+ protocol. Dr. Marik explains the importance of understanding the dynamics of the disease, how it progresses, early treatment, why corticosteroids and vitamin C work together in combating the inflamation and cytokine activation, melatonin and other details of the therapeutics utilized.

https://covid19criticalcare.com/

July 15, 2020 Dr. Paul Marik, author of the MATH+ Protocol and Chief of Pulmonary and Critical Care at the Eastern Virginia Medical School at Norfolk Virginia confers the importance of treating Covid-19 early and aggressively. Dr. Marik clarifies the various stages of the illness and the protocols deployed to treat patients at each stage and how it becomes increasing more difficult to reverse as the patient progresses into the later stages of the disease. 

https://www.evms.edu/covid-19/covid_care_for_clinicians/

MATH+ Protocol

https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf

MATH+ Protocol Summary

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik-Covid-Protocol-Summary.pdf

Dr. Trevor Marshall Explains the Workings of Ivermectin

August 2, 2020 Dr. Trevor Marshall explains how one dose of 15mg to 20mg of Ivermectin in a typical adult prevents the the Importin Alpha and Beta proteins from binding to dimers preventing the transportation of viral replicase into the cell nucleus where the replication process occurs. Furthermore Ivermectin’s action is theorized to work on other RNA viruses beyond Covid-19 such as Influenza.

Dr. Jean-Jacques Rajter and Dr. Juliana Cepelowicz Rajter Broward County Ivermectin Success

July 15, 2020 Dr. Jean-Jacques Rajter and Dr. Juliana Cepelowicz Rajter provides review of how they discovered Ivermectin, their clinical successes administering Ivermectin to their patients and how Ivermectin became a standard of care for Covid-19 patients at Broward Health Medical Center in Florida. Rajter provides an update of their status with the publishing of their data and currently organizing a randomized control trial with a cooperative of hospitals.

Dr. Jean-Jacques Rajter and Dr. Juliana Cepelowicz Rajter Retrospective Observational Data

https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2

https://www.trialsitenews.com/ivermectin-breaking-into-american-news-as-doctors-come-forward-share-treatments-for-covid-19/

Dr. Jean-Jacques Rajter Contact and Insights

http://pscflorida.com/

https://www.trialsitenews.com/broward-county-doctor-using-ivermectin-off-label-combo-on-covid-19-patients-it-is-working-secures-county-health-protocol-approval/

Dr. Seheult's Reasoning for Treating Covid-19 Patients with Ivermectin

“Studies are still pending but, Ivermectin has been a medication used for decades. We know the side effect profile of it. Its a relatively safe medication, again the question is do we use it and find out later that it didn’t work ok it didn’t work, or do we not use it and find out that it may work or it does work and we didn’t use it. I think I would rather make the first error than the second.”

Dr. Roger Seheult of Medcram – Pulmonologist at Beaver Medical Group Banning California

Thomas Borody Ivermectin + Doxycycline + Zinc Triple Therapy

September 12, 2020 Gastroenterologist and Infectious Diseases Professor Thomas Borody specializes in repurposing combined medications developed curative treatments for peptic ulcers and Crohns Disease. Professor Borody repurposed medications treats patients for 10 days with an appropriate dose of Ivermectin, Doxycycline and Zinc daily with 92% to 100% cure rate. Focus on this treatment is for out patients before patients develop symptoms while the viral load is low.

Professor Borody goes on to mention that its a similar strategy to Dr. Zelenko’s approach and he has not been listened to.

Covexit inquires whether the data will be gathered, analyzed and published, Professor Borody responds,

“We will be comparing straight observational data with retrospective historical data from the

September 7, 2020 Gastroenterologist Dr. Mark Hobart speaks on his experience treating his patients early with Professor Thomas Borody’s treatment Ivermectin + Doxycycline + Zinc and has been shown to be clinically effective and harmless supporting its use as opposed to the alternative which is no treatment. Dr. Hobart has not encountered any resistance from the Australian Medical authorities but no encouragement which he hoped there would be encouragement in the absence of any treatment at the moment.

Professor Thomas Borody a gastroenterologist provides insights on how approved medications do not go through trials. Borody advocates for the use of Ivermectin and companion medications including Doxycycline and Zinc to save lives and reiterates the safety profile of Ivermectin.

August 13, 2020 Professor Thomas Borody Proposal for Ivermectin

https://www.trialsitenews.com/more-news-on-dr-borodys-ivermectin-proposal/

Professor Thomas Borody is an expert in the areas drug repurposing specifically for intracellular bacteria and viruses and surprised with how little side effects Ivermectin has how effective Ivermectin + Doxycycline + Zinc together work to treat Sars-Cov-2.

July 27, 2020 Trialsite reviews Dr. Tarek Alam Ivermectin study treating 500 patients with the anti-parasitic drug.

August 16, 2020 Bangledesh Ivermectin Study

https://www.trialsitenews.com/bangladesh-study-suggests-that-ivermectin-combo-can-treat-covid-19/

WhiteBoard Doctor provides an in depth analysis of Ivermectin, Hydroxychloroquine, and Azithromycin Combination Therapy For COVID-19: Iraq Pilot Trial

Trialsite goes to Peru to document the widespread Ivermectin accessibility and self medicating phenomenon amongst Peruvians and how Peru’s health system administers Ivermectin to reduce spread of Covid-19.

FDA Warning for People Self Medicating Ivermectin Products Intended for Animals

“FDA is concerned about the health of consumers who may self-medicate by taking ivermectin products intended for animals, thinking they can be a substitute for ivermectin intended for humans. People should never take animal drugs, as the FDA has only evaluated their safety and effectiveness in the particular animal species for which they are labeled. These animal drugs can cause serious harm in people. People should not take any form of ivermectin unless it has been prescribed to them by a licensed health care provider and is obtained through a legitimate source.”

Full FDA Letter:

https://www.fda.gov/animal-veterinary/product-safety-information/fda-letter-stakeholders-do-not-use-ivermectin-intended-animals-treatment-covid-19-humans

Dr. Harvey Risch Yale School of Medicine and Public Health Epidemiologist

September 5, 2020 Dr. Harvey Risch reiterates, this disease must be treated early particularly in high risk groups ages 60 and over and patients with comorbid and chronic illnesses high blood pressure, diabetes, hypertension, cancers etc. There is uniform benefit in treating these people with HCQ. Refinement of medical practice, HCQ works best with Zinc. We deal with empirical data and that is what tells us best about its use in a controlled manner as best as possible.

August 23, 2020 Dr. Harvey Risch emphasizes again the unassailable evidence for the early outpatient treatment of Covid19 carriers in high risk groups over the age of 60 with comorbid and immuno compromised conditions. Risch goes on to speak of an incident with Dr. Fauci in 1987 where he had refused to recommend the use of the Antibiotic Bactrim to prophylax and treat AIDS patients from succumbing to Pneumocystis Pneumonia that costed the lives of 17,000 AIDS patients during the two years that activists took to raise the money by themselves to fund and complete the randomized control trial for Bactrim Dr. Fauci required, which parallels the same situation Hydroxychloroquine is experiencing today.

The Huffington Post February 21, 2014 article details the tragedy of 1987 below:

https://www.huffpost.com/entry/whitewashing-aids-history_b_4762295

August 7, 2020 Dr. Harvey Risch offers scathing remarks of doctors and clinicians who are unable to distinguish which groups should be treated, which groups should not be treated with Hydroxychloroquine and companion medications, ought to have their medical acumen questioned.

Dr. Harvey Risch Newsweek Article, The Key to Defeating COVID-19 Already Exists. We Need to Start Using It | Opinion Piece

https://www.newsweek.com/key-defeating-covid-19-already-exists-we-need-start-using-it-opinion-1519535

Dr. Harvey Risch states in his Washington Examiner Article:

If you are told that HCQ does not work, ask this question:

  1. Does it not work in those who have just started to have symptoms, or those sick enough to require hospitalization?

Randomized controlled trials show no benefit for HCQ:

  1. In which group of patients does HCQ show no benefit?

washingtonexaminer.com/opinion/hydroxychloroquine-works-in-high-risk-patients-and-saying-otherwise-is-dangerous

Dr. Harvey Risch Epidemiologist at the Yale School of Medicine and Public Health paper “Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis” published on May 27, 2020 and updated.

https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaa093/5847586

Balram Bhargava India Council of Medical Research Delhi Director General

May 22, 2020 Hindustan Times Cross referencing how other health systems and practice of medicine in other regions have been coping and reducing the spread Sars-Cov-2, India’s ICMR India Council of Medical Research and the reasoning provided by their Director General Balram Bhargava provided an explanation that appears to fulfill the demands of emergency situations. He states that repurposing medications and the decision to use Hydroxychloroquine HCQ for Covid19 positive patients, pre exposure prophylaxis for health care workers, front line workers and Covid19 positive close contacts were based on Biological Plausibility from:

  1. In Vitro studies of the anti viral, immunological effects of HCQ on Covid19
  2. Availability of HCQ
  3. Safety of HCQ

They determine that HCQ and companion medications may work and ICMR opted out of randomized control trials for medications that may work opting for on the field evidence gathering in tandem with dispensing, prescribing and administering HCQ. Bhargava states that the risk benefit they find that possibly we should not deny Health Care Workers dealing with Covid-19 patients on the front line and should continue to utilize PPE.

Revised May 22, 2020 Advisory on the use of Hydroxychloroquine (HCQ) as prophylaxis for SARS-CoV-2 infection (in supersession of previous advisory dated 23rd March, 2020) 

https://www.icmr.gov.in/pdf/covid/techdoc/V5_Revised_advisory_on_the_use_of_HCQ_SARS_CoV2_infection.pdf

India Journal of Medical Research

Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19 Chatterjee P, Anand T, Singh KJ, Rasaily R, Singh R, Das S, Singh H, Praharaj I, Gangakhedkar RR, Bhargava B, Panda S – Indian J Med Res

http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2020;volume=151;issue=5;spage=459;epage=467;aulast=Chatterjee 

Key take away of the Hydroxychloroquine Prophylaxis study above;

  1. Hydroxychloroquine prophylaxis: Distribution of cases and controls across exposures in univariate analysis indicated the association of risk (P=0.087) of SARS-CoV-2 infection with the lack of HCQ prophylaxis [Table 3]. However, the number of maintenance doses taken by HCWs following the intake of a loading dose revealed a protective dose-response relationship. Consumption of four or more maintenance doses was associated with a significant decline in the risk of SARS-CoV-2 infection among the study participants [Figure 1]. The significant declining trend had an overall χ[2] value of 48.88 (P <0.001).
  2. Of the 172 cases and 193 controls reporting HCQ intake, no significant difference in the occurrence of adverse drug reactions was noted. The three most common side effects of HCQ as reported by the cases and controls were nausea (5 vs. 8%), headache (6 vs. 5%) and diarrhoea (5 vs. 4%). While none of the controls on HCQ complained of palpitations, only one case (1/172, 0.6%) reported the same. Gastrointestinal symptoms such as acidity and vomiting following HCQ intake ranged from 0.6 per cent in cases to about two per cent in controls. Very few cases (0.6%) and controls (1.4%) had skin rashes after consuming HCQ.
  3. Multivariate analysis: Factors found associated (P <0.1) with SARS-CoV-2 infection among HCWs in univariate analysis and having biological plausibility were entered into multivariate model. In case of conceivable similarity between explanatory variables, one was chosen over another to avoid collinearity. For example, PPE rather than individual items (cap, mask, gown, glove, etc.) of PPE was included in the model. Adjusted for[25] gender, use of PPE, endotracheal intubation, different intensity of exposure to prophylactic HCQ and testing place with date, intake of 4-5 maintenance doses of HCQ [adjusted odds ratio (AOR): 0.44; 95% confidence interval (CI): 0.22-0.88; P=0.02] was found to independently impart the protective effect against SARS-CoV-2 infection among HCWs [Table 4]. Notwithstanding this effect, the advantage of PPE usage was also independently indicated by the multivariate model. Noticeably, six or more prophylactic doses of HCQ used by HCWs had a remarkably high (>80%) protective effect against SARS-CoV-2 infection.

August 13, 2020 Telemedicine IGMC Shimla Dr. Sanjay K Mahajan associate professor of Medicne at IGMC Shimla provides details of the role of Hydroxychloroquine as a therapeutic and prophylactic.

FDA Disclaimer:

* The statements made above and the efficacy of these measures have not been confirmed or approved by the FDA. These measures are internal implementations and are not intended to diagnose, cure, treat , prevent disease or other ailments. All information here is for educational purposes only. It is highly recommended to seek your own research and due diligence to form your conclusions. The information here is not intended to substitute or serve as an alternative to health care professionals, practitioners and FDA clinical research findings.

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